High throughput evaluation of gamma-H2AX
نویسندگان
چکیده
منابع مشابه
High throughput evaluation of gamma-H2AX
The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical impact. Phosphorylation of histone H2AX to form gamma-H2AX is a known marker for irradiation-induced DNA DSBs. However, the first generation assay involves the use of immunofluorescent stai...
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Cancer immunotherapy has been revolutionised by the use monoclonal antibodies (mAb) that function through their interaction with Fc gamma receptors (FcγRs). The low-affinity FcγR genes are highly homologous, map to a complex locus at 1p23 and harbour single nucleotide polymorphisms (SNPs) and copy number variation (CNV) that can impact on receptor function and response to therapeutic mAbs. This...
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Fig 4 is incorrect. The figure is an older version, which contains an inaccurate summary of data. The authors have provided a corrected version here. Copyright: © 2016 Hargreaves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author ...
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Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model
There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for such a model is the minipig. Here, we evaluate the minipig for its potential in γ-H2AX-based biodosimetry after exposure to ionizing radiation using both Cs137 and Co60 sources. γ-H2AX foci were enumerated in blood lymphocytes and normal fi...
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ژورنال
عنوان ژورنال: Radiation Oncology
سال: 2009
ISSN: 1748-717X
DOI: 10.1186/1748-717x-4-31